Vatican City to Siena Buses

Vatican City to Siena buses

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Trip Overview

The average bus between Vatican City and Siena takes 3h 37m and the fastest bus takes 3h 21m. The bus service runs several times per day from Vatican City to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 37m
Duration: 241 km
Distance: €28
Average price: Every 3 hours
Frequency

Line 490 bus, bus

best

Take the bus from Giulio Cesare/Ottaviano to Roma, Autostazione Tiburtinabus 490
Take the bus from Roma, Autostazione Tiburtina to Sienabus 1550 / ...

4h 11m

€18–38

Vatican City to Siena bus times

Buses run every 3 hours between Vatican City and Siena. The earliest departure is at 5:42 AM in the morning, and the last departure from Vatican City is at 9:03 PM which arrives into Siena at 12:40 AM. All services require a transfer, and take on average 3h 37m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

7:41 AM → 11:25 AM
3h 43m • 1 change
10:33 AM → 2:20 PM
3h 46m • 1 change
11:18 AM → 3:00 PM
3h 41m • 1 change
1:19 PM → 5:00 PM
3h 40m • 1 change
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Departing Saturday, November 7, 2026

5:53 AM → 9:15 AM
3h 21m • 1 change
7:11 AM → 10:35 AM
3h 23m • 1 change
7:56 AM → 11:25 AM
3h 28m • 1 change
10:36 AM → 2:20 PM
3h 43m • 1 change
Show more

Departing Sunday, November 8, 2026

5:42 AM → 9:15 AM
3h 32m • 1 change
7:02 AM → 10:35 AM
3h 32m • 1 change
7:51 AM → 11:25 AM
3h 33m • 1 change
10:33 AM → 2:20 PM
3h 46m • 1 change
Show more

Departing Monday, November 9, 2026

5:50 AM → 9:15 AM
3h 24m • 1 change
7:04 AM → 10:35 AM
3h 30m • 1 change
7:41 AM → 11:25 AM
3h 43m • 1 change
10:33 AM → 2:20 PM
3h 46m • 1 change
Show more

Departing Tuesday, November 10, 2026

5:50 AM → 9:15 AM
3h 24m • 1 change
11:18 AM → 3:00 PM
3h 41m • 1 change
1:19 PM → 5:00 PM
3h 40m • 1 change
4:48 PM → 8:24 PM
3h 35m • 1 change
Show more

Departing Wednesday, November 11, 2026

11:18 AM → 3:00 PM
3h 41m • 1 change
1:19 PM → 5:00 PM
3h 40m • 1 change
4:48 PM → 8:24 PM
3h 35m • 1 change
6:15 PM → 9:55 PM
3h 39m • 1 change
Show more

Departing Thursday, November 12, 2026

5:50 AM → 9:15 AM
3h 24m • 1 change
7:04 AM → 10:35 AM
3h 30m • 1 change
7:41 AM → 11:25 AM
3h 43m • 1 change
10:33 AM → 2:20 PM
3h 46m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Vatican City to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Vatican City to Siena buses

Find Transport to Siena

Trip Overview

Line 490 bus, bus

Vatican City to Siena bus times

Departing Friday, November 6, 2026

7:41 AM → 11:25 AM

10:33 AM → 2:20 PM

11:18 AM → 3:00 PM

1:19 PM → 5:00 PM

Departing Saturday, November 7, 2026

5:53 AM → 9:15 AM

7:11 AM → 10:35 AM

7:56 AM → 11:25 AM

10:36 AM → 2:20 PM

Departing Sunday, November 8, 2026

5:42 AM → 9:15 AM

7:02 AM → 10:35 AM

7:51 AM → 11:25 AM

10:33 AM → 2:20 PM

Departing Monday, November 9, 2026

5:50 AM → 9:15 AM

7:04 AM → 10:35 AM

7:41 AM → 11:25 AM

10:33 AM → 2:20 PM

Departing Tuesday, November 10, 2026

5:50 AM → 9:15 AM

11:18 AM → 3:00 PM

1:19 PM → 5:00 PM

4:48 PM → 8:24 PM

Departing Wednesday, November 11, 2026

11:18 AM → 3:00 PM

1:19 PM → 5:00 PM

4:48 PM → 8:24 PM

6:15 PM → 9:55 PM

Departing Thursday, November 12, 2026

5:50 AM → 9:15 AM

7:04 AM → 10:35 AM

7:41 AM → 11:25 AM

10:33 AM → 2:20 PM

Frequently asked questions

What companies run services between Vatican City and Siena, Italy?

Bus from Giulio Cesare/Ottaviano to Roma, Autostazione Tiburtina

Bus from Roma, Autostazione Tiburtina to Siena

Bus from Roma, Autostazione Tiburtina to Siena

Bus from Roma - Via Vincenzo Giudice to Siena

Where to next?

Bus trips from Vatican City

Bus trips to Siena

Alternative transport options