Bus Vatican City to Siena from €28 | Tickets & Timetables

Vatican City to Siena buses

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Trip Overview

The average bus between Vatican City and Siena takes 3h 41m and the fastest bus takes 3h 26m. The bus service runs several times per day from Vatican City to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 41m
Duration: 243 km
Distance: €28
Average price: Every 3 hours
Frequency

Line 490 bus, bus

best

Take the bus from Candia/Mocenigo to Roma, Autostazione Tiburtinabus 490 / ...
Take the bus from Roma, Autostazione Tiburtina to Sienabus 1550 / ...

4h 26m

€18–44

Vatican City to Siena bus times

Buses run every 3 hours between Vatican City and Siena. The earliest departure is at 5:48 AM in the morning, and the last departure from Vatican City is at 8:58 PM which arrives into Siena at 12:40 AM. All services require a transfer, and take on average 3h 41m. The schedules shown below are for the next available departures.

Departing Tuesday, August 11, 2026

1:21 PM → 5:00 PM
3h 38m • 1 change
4:44 PM → 8:24 PM
3h 39m • 1 change
6:14 PM → 9:55 PM
3h 40m • 1 change
8:58 PM → 12:40 AM
Arrives next day
3h 41m • 1 change

Departing Wednesday, August 12, 2026

11:16 AM → 3:00 PM
3h 43m • 1 change
1:21 PM → 5:00 PM
3h 38m • 1 change
2:47 PM → 6:35 PM
3h 47m • 1 change
4:44 PM → 8:24 PM
3h 39m • 1 change
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Departing Thursday, August 13, 2026

5:48 AM → 9:15 AM
3h 26m • 1 change
6:53 AM → 10:35 AM
3h 41m • 1 change
7:35 AM → 11:25 AM
3h 49m • 1 change
10:25 AM → 2:20 PM
3h 54m • 1 change
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Departing Friday, August 14, 2026

5:48 AM → 9:15 AM
3h 26m • 1 change
6:53 AM → 10:35 AM
3h 41m • 1 change
7:35 AM → 11:25 AM
3h 49m • 1 change
10:25 AM → 2:20 PM
3h 54m • 1 change
Show more

Departing Saturday, August 15, 2026

5:48 AM → 9:15 AM
3h 26m • 1 change
6:44 AM → 10:35 AM
3h 50m • 1 change
7:42 AM → 11:25 AM
3h 42m • 1 change
10:29 AM → 2:20 PM
3h 50m • 1 change
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Departing Sunday, August 16, 2026

5:48 AM → 9:15 AM
3h 26m • 1 change
6:44 AM → 10:35 AM
3h 50m • 1 change
7:42 AM → 11:25 AM
3h 42m • 1 change
10:29 AM → 2:20 PM
3h 50m • 1 change
Show more

Departing Monday, August 17, 2026

5:48 AM → 9:15 AM
3h 26m • 1 change

Frequently asked questions

Want to know about travelling from Vatican City to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.