The average bus between Villeneuve-lès-Avignon and Lyon takes 4h 11m and the fastest bus takes 3h 40m. There is a bus service every few hours from Villeneuve-lès-Avignon to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Villeneuve-lès-Avignon and Lyon. The earliest departure is at 7:20 AM in the morning, and the last departure from Villeneuve-lès-Avignon is at 9:09 PM which arrives into Lyon at 12:50 AM. All services require a transfer at Poste and take an average of 4h 11m. The schedules shown below are for the next available departures.


4h 12m • 2 changes


4h 9m • 2 changes


4h 51m • 2 changes


4h 24m • 2 changes


4h 12m • 2 changes


4h 9m • 2 changes


4h 51m • 2 changes


4h 24m • 2 changes


4h 5m • 2 changes


4h 49m • 2 changes


4h 54m • 2 changes


5h • 2 changes


4h 30m • 2 changes


3h 55m • 2 changes


4h 18m • 2 changes


3h 52m • 2 changes
Want to know about travelling from Villeneuve-lès-Avignon to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Villeneuve-lès-Avignon to Lyon. However, there are services departing from Villeneuve-lès-Avignon station and arriving at Lyon station via Lyon. The journey, including transfers, takes approximately 4h 11m.
Villeneuve-lès-Avignon to Lyon bus services, operated by Tecelys, depart from Avignon station.
Villeneuve-lès-Avignon to Lyon bus services, operated by Tecelys, arrive at Lyon station.
The distance between Villeneuve-lès-Avignon and Lyon is 198.5 km. The road distance is 246 km.
FlixBus operates a bus from Avignon to Lyon every 4 hours. Tickets cost €18–35 and the journey takes 2h 40m. BlaBlaCar Bus also services this route every 4 hours.