Vista to Otay Mesa Buses

Vista to Otay Mesa buses

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Trip Overview

The average bus between Vista and Otay Mesa takes 4h 1m and the fastest bus takes 3h 11m. There is a bus service every few hours from Vista to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 1m
Duration: 82 mi
Distance: $20
Average price: Hourly
Frequency

Line 305 bus, bus, line 225 bus

best

Take the bus from Santa Fe Ave & Broadway to Escondido Transit Center Stall 6bus 305
Take the bus from Escondido Transit Center to Broadway & Park Blbus 235 / ...
Take the bus from Broadway & Park Bl to Otay Mesa Transit Centerbus 225

3h 51m

$8–20

Vista to Otay Mesa bus times

Buses run hourly between Vista and Otay Mesa. The earliest departure is at 4:34 AM at night, and the last departure from Vista is at 11:14 PM which arrives into Otay Mesa at 7:18 AM. All services require a transfer at Escondido Transit Center Stall 6 and take an average of 4h 1m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

4:34 AM → 7:48 AM
3h 14m • 3 changes
5:03 AM → 8:18 AM
3h 15m • 3 changes
5:30 AM → 8:48 AM
3h 18m • 3 changes
6:34 AM → 9:45 AM
3h 11m • 3 changes
Show more

Departing Thursday, November 5, 2026

4:34 AM → 7:48 AM
3h 14m • 3 changes
5:03 AM → 8:18 AM
3h 15m • 3 changes
5:30 AM → 8:48 AM
3h 18m • 3 changes
6:34 AM → 9:45 AM
3h 11m • 3 changes
Show more

Departing Friday, November 6, 2026

4:34 AM → 7:48 AM
3h 14m • 3 changes
5:03 AM → 8:18 AM
3h 15m • 3 changes
5:30 AM → 8:48 AM
3h 18m • 3 changes
6:34 AM → 9:45 AM
3h 11m • 3 changes
Show more

Departing Saturday, November 7, 2026

6:02 AM → 9:28 AM
3h 26m • 3 changes
7:02 AM → 10:28 AM
3h 26m • 3 changes
8:07 AM → 11:28 AM
3h 21m • 3 changes
9:07 AM → 12:28 PM
3h 21m • 3 changes
Show more

Departing Sunday, November 8, 2026

6:02 AM → 9:43 AM
3h 41m • 3 changes
7:02 AM → 10:43 AM
3h 41m • 3 changes
8:07 AM → 11:43 AM
3h 36m • 3 changes
9:07 AM → 12:43 PM
3h 36m • 3 changes
Show more

Departing Monday, November 9, 2026

4:34 AM → 7:48 AM
3h 14m • 3 changes
5:03 AM → 8:18 AM
3h 15m • 3 changes
5:30 AM → 8:48 AM
3h 18m • 3 changes
6:34 AM → 9:45 AM
3h 11m • 3 changes
Show more

Departing Tuesday, November 10, 2026

4:34 AM → 7:48 AM
3h 14m • 3 changes
5:03 AM → 8:18 AM
3h 15m • 3 changes
5:30 AM → 8:48 AM
3h 18m • 3 changes
6:34 AM → 9:45 AM
3h 11m • 3 changes
Show more

Frequently asked questions

Want to know about travelling from Vista to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Find Transport to Otay Mesa

Trip Overview

Line 305 bus, bus, line 225 bus

Vista to Otay Mesa bus times

Departing Wednesday, November 4, 2026

4:34 AM → 7:48 AM

5:03 AM → 8:18 AM

5:30 AM → 8:48 AM

6:34 AM → 9:45 AM

Departing Thursday, November 5, 2026

4:34 AM → 7:48 AM

5:03 AM → 8:18 AM

5:30 AM → 8:48 AM

6:34 AM → 9:45 AM

Departing Friday, November 6, 2026

4:34 AM → 7:48 AM

5:03 AM → 8:18 AM

5:30 AM → 8:48 AM

6:34 AM → 9:45 AM

Departing Saturday, November 7, 2026

6:02 AM → 9:28 AM

7:02 AM → 10:28 AM

8:07 AM → 11:28 AM

9:07 AM → 12:28 PM

Departing Sunday, November 8, 2026

6:02 AM → 9:43 AM

7:02 AM → 10:43 AM

8:07 AM → 11:43 AM

9:07 AM → 12:43 PM

Departing Monday, November 9, 2026

4:34 AM → 7:48 AM

5:03 AM → 8:18 AM

5:30 AM → 8:48 AM

6:34 AM → 9:45 AM

Departing Tuesday, November 10, 2026

4:34 AM → 7:48 AM

5:03 AM → 8:18 AM

5:30 AM → 8:48 AM

6:34 AM → 9:45 AM

Frequently asked questions

What companies run services between Vista, CA, USA and Otay Mesa, CA, USA?

Bus from Santa Fe Ave & Broadway to Escondido Transit Center Stall 6

Bus from Escondido Transit Center to Broadway & Park Bl

Bus from Broadway & Park Bl to Otay Mesa Transit Center

Bus trips from Vista

Bus trips to Otay Mesa

Alternative transport options