The average bus between Vista and Otay Mesa takes 4h 7m and the fastest bus takes 3h 21m. There is a bus service every few hours from Vista to Otay Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Vista and Otay Mesa. The earliest departure is at 4:34 AM at night, and the last departure from Vista is at 11:12 PM which arrives into Otay Mesa at 7:48 AM. All services require a transfer at Escondido Transit Center Stall 6 and take an average of 4h 7m. The schedules shown below are for the next available departures.



3h 26m • 3 changes



3h 26m • 3 changes



3h 21m • 3 changes



3h 21m • 3 changes



3h 41m • 3 changes



3h 41m • 3 changes



3h 36m • 3 changes



3h 36m • 3 changes



3h 44m • 3 changes



3h 45m • 3 changes



3h 45m • 3 changes



3h 41m • 3 changes
Want to know about travelling from Vista to Otay Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Vista to Otay Mesa. However, there are services departing from Vista station and arriving at Otay Mesa station via Escondido Transit Center Stall 6. The journey, including transfers, takes approximately 4h 7m.
Vista to Otay Mesa bus services, operated by North County Transit, depart from Santa Fe Ave & Broadway station.
Vista to Otay Mesa bus services, operated by North County Transit, arrive at Otay Mesa Transit Center station.
The distance between Vista and Otay Mesa is 74.7 km. The road distance is 133 km.
You can take a bus from Santa Fe Ave & Broadway to Otay Mesa Rd & Cactus Rd via Escondido Transit Center Stall 6, Escondido Transit Center, Broadway & Park Bl, and Otay Mesa Transit Center in around 3h 50m.