The average bus between Würzburg and Prague takes 6h 16m and the fastest bus takes 5h 20m. The bus service runs several times per day from Würzburg to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Würzburg and Prague. The earliest departure is at 1:35 AM at night, and the last departure from Würzburg is at 3:25 PM which arrives into Prague at 9:30 PM. All services require a transfer, and take on average 6h 16m. The schedules shown below are for the next available departures.

5h 20m • 1 change

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6h • 1 change

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6h 30m • 1 change

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6h • 1 change

6h 35m • 1 change
Want to know about travelling from Würzburg to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Würzburg to Prague. However, there are services departing from Würzburg station and arriving at Prague station via Nuremberg central bus station station. The journey, including transfers, takes approximately 6h 16m.
Würzburg to Prague bus services, operated by FlixBus, depart from Würzburg Main Station.
Würzburg to Prague bus services, operated by FlixBus, arrive at Praha, ÚAN Florenc station.
Book your Würzburg to Prague bus tickets online with FlixBus.
The distance between Würzburg and Prague is 321.5 km. The road distance is 402 km.
You can take a bus from Würzburg Main Station to Praha, ÚAN Florenc via Nuremberg central bus station in around 6h 3m.