The average bus between Wayne and Buffalo takes 12h 32m and the fastest bus takes 11h 51m. The bus service runs several times per day from Wayne to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Wayne and Buffalo. The earliest departure is at 6:46 AM in the morning, and the last departure from Wayne is at 8:08 PM which arrives into Buffalo at 8:45 AM. All services require a transfer at Gray 30th St Station and take an average of 12h 32m. The schedules shown below are for the next available departures.
Arrives next day



12h 11m • 3 changes
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12h 37m • 3 changes



12h 4m • 3 changes



12h 57m • 3 changes
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12h 11m • 3 changes
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11h 51m • 3 changes



12h 4m • 3 changes



12h 57m • 3 changes
Arrives next day



12h 11m • 3 changes
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12h 37m • 3 changes



12h 31m • 3 changes
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12h 46m • 3 changes
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14h 25m • 3 changes
Want to know about travelling from Wayne to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Wayne to Buffalo. However, there are services departing from Wayne station and arriving at Buffalo station via Scranton. The journey, including transfers, takes approximately 12h 32m.
Wayne to Buffalo bus services, operated by SEPTA, depart from Philadelphia station.
Wayne to Buffalo bus services, operated by SEPTA, arrive at Buffalo station.
The distance between Wayne and Buffalo is 429.5 km. The road distance is 671 km.
You can take a train from Wayne to Buffalo via Gray 30th St Station, Philadelphia, and Scranton Bus Station in around 11h 7m.