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Wayne to Buffalo buses

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Trip Overview

The average bus between Wayne and Buffalo takes 14h 25m and the fastest bus takes 11h 59m. The bus service runs several times per day from Wayne to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

14h 25m
Duration
416 mi
Distance
$119
Average price
3 times a day
Frequency

Wayne to Buffalo bus times

Buses run 3 times a day between Wayne and Buffalo. The earliest departure is at 6:00 AM in the morning, and the last departure from Wayne is at 8:46 PM which arrives into Buffalo at 8:45 AM. All services require a transfer at Gray 30th St Station and take an average of 14h 25m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

  •  → 

    SEPTASEPTAGreyhound USAFlixbus USA12h 50m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA14h 5m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA11h 59m • 3 changes

Departing Tuesday, November 10, 2026

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    SEPTASEPTAGreyhound USAFlixbus USA14h 35m • 3 changes
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    Arrives next day

    SEPTASEPTAGreyhound USAFlixbus USA17h 40m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAGreyhound USAGreyhound USA20h 39m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    SEPTASEPTAGreyhound USAFlixbus USA12h 50m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAGreyhound USAFlixbus USA17h 5m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAGreyhound USAFlixbus USA20h 14m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    SEPTASEPTAGreyhound USAFlixbus USA12h 50m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA14h 5m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAGreyhound USAFlixbus USA12h 42m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA11h 59m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    SEPTASEPTAGreyhound USAFlixbus USA12h 50m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA14h 5m • 3 changes
  •  → 

    Arrives next day

    SEPTASEPTAFlixbus USAFlixbus USA11h 59m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    SEPTASEPTAGreyhound USAFlixbus USA12h 15m • 3 changes

Frequently asked questions

Want to know about travelling from Wayne to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Wayne to Buffalo.ExpandLaunch map view
  • Distance: 415.9 mi
  • Duration: 14h 25m

What companies run services between Wayne, PA, USA and Buffalo, NY, USA?

You can take a train from Wayne to Buffalo via Gray 30th St Station, Philadelphia 30th St Station, and Scranton Bus Station in around 11h 7m.

Operators