The average bus between Wayne and Buffalo takes 13h 15m and the fastest bus takes 11h 59m. The bus service runs several times per day from Wayne to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Wayne and Buffalo. The earliest departure is at 6:00 AM in the morning, and the last departure from Wayne is at 8:46 PM which arrives into Buffalo at 8:45 AM. All services require a transfer at Gray 30th St Station and take an average of 13h 15m. The schedules shown below are for the next available departures.



12h 15m • 3 changesArrives next day



13h 20m • 3 changesArrives next day



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12h 50m • 3 changesArrives next day



14h 5m • 3 changesArrives next day



11h 59m • 3 changes


12h 50m • 3 changesArrives next day



17h 5m • 3 changesArrives next day



11h 59m • 3 changes


12h 50m • 3 changesArrives next day



17h 5m • 3 changesArrives next day



11h 59m • 3 changesWant to know about travelling from Wayne to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Wayne to Buffalo. However, there are services departing from Wayne station and arriving at Buffalo station via Scranton. The journey, including transfers, takes approximately 13h 15m.
Wayne to Buffalo bus services, operated by SEPTA, depart from Philadelphia 30th St Station.
Wayne to Buffalo bus services, operated by SEPTA, arrive at Buffalo station.
The distance between Wayne and Buffalo is 429.5 km. The road distance is 671 km.
You can take a train from Wayne to Buffalo via Gray 30th St Station, Philadelphia 30th St Station, and Scranton Bus Station in around 11h 6m.