The average bus between Wayne and Syracuse takes 10h 10m and the fastest bus takes 7h 58m. The bus service runs several times per day from Wayne to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Wayne and Syracuse. The earliest departure is at 6:46 AM in the morning, and the last departure from Wayne is at 8:08 PM which arrives into Syracuse at 1:35 PM. All services require a transfer at Gray 30th St Station and take an average of 10h 10m. The schedules shown below are for the next available departures.



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Arrives next day



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Want to know about travelling from Wayne to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Wayne to Syracuse. However, there are services departing from Wayne station and arriving at Syracuse station via Scranton. The journey, including transfers, takes approximately 10h 10m.
Wayne to Syracuse bus services, operated by SEPTA, depart from Philadelphia 30th St Station.
Wayne to Syracuse bus services, operated by SEPTA, arrive at Syracuse Bus Station.
The distance between Wayne and Syracuse is 340 km. The road distance is 457 km.
You can take a train from Wayne to Syracuse Bus Station via Gray 30th St Station, Philadelphia 30th St Station, and Scranton Bus Station in around 8h 11m.