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West Lafayette to Des Moines buses

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Trip Overview

The average bus between West Lafayette and Des Moines takes 15h 14m and the fastest bus takes 9h 10m. The bus service runs several times per day from West Lafayette to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 14m
Duration
461 mi
Distance
$101
Average price
Twice daily
Frequency

West Lafayette to Des Moines bus times

Buses run twice daily between West Lafayette and Des Moines. The earliest departure is at 6:40 AM in the morning, and the last departure from West Lafayette is at 11:05 PM which arrives into Des Moines at 2:35 PM. All services require a transfer, and take on average 15h 14m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USA20h 30m • 1 change

Departing Thursday, November 12, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA20h 30m • 1 change

Departing Friday, November 13, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
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    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Saturday, November 14, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Sunday, November 15, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
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    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Frequently asked questions

Want to know about travelling from West Lafayette to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from West Lafayette to Des Moines.ExpandLaunch map view
  • Distance: 461 mi
  • Duration: 15h 14m

What companies run services between West Lafayette, IN, USA and Des Moines, IA, USA?

You can take a bus from Lafayette Bus Stop to Des Moines via Chicago Bus Station in around 9h 45m.

Operators