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West Lafayette to Des Moines buses

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Trip Overview

The average bus between West Lafayette and Des Moines takes 13h 22m and the fastest bus takes 9h 10m. The bus service runs several times per day from West Lafayette to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

13h 22m
Duration
455 mi
Distance
$101
Average price
3 times a day
Frequency

West Lafayette to Des Moines bus times

Buses run 3 times a day between West Lafayette and Des Moines. The earliest departure is at 6:40 AM in the morning, and the last departure from West Lafayette is at 11:05 PM which arrives into Des Moines at 2:35 PM. All services require a transfer, and take on average 13h 22m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

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    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Tuesday, November 3, 2026

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    Flixbus USAGreyhound USA10h 15m • 1 change
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    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Wednesday, November 4, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
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    Flixbus USAGreyhound USA9h 10m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA20h 30m • 1 change

Departing Thursday, November 5, 2026

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    Greyhound USAGreyhound USA13h 5m • 1 change
  •  → 

    Flixbus USAGreyhound USA9h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA20h 30m • 1 change

Departing Friday, November 6, 2026

  •  → 

    Greyhound USAGreyhound USA13h 5m • 1 change
  •  → 

    Flixbus USAGreyhound USA9h 10m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Saturday, November 7, 2026

  •  → 

    Greyhound USAGreyhound USA13h 5m • 1 change
  •  → 

    Flixbus USAGreyhound USA9h 10m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Sunday, November 8, 2026

  •  → 

    Greyhound USAGreyhound USA13h 5m • 1 change
  •  → 

    Flixbus USAGreyhound USA9h 10m • 1 change
  •  → 

    Arrives next day

    Flixbus USAGreyhound USA16h 30m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Flixbus USAGreyhound USA9h 10m • 1 change

Frequently asked questions

Want to know about travelling from West Lafayette to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from West Lafayette to Des Moines.ExpandLaunch map view
  • Distance: 454.6 mi
  • Duration: 13h 22m

What companies run services between West Lafayette, IN, USA and Des Moines, IA, USA?

You can take a bus from Lafayette Bus Stop to Des Moines via Chicago Bus Station in around 9h 45m.

Operators