The average bus between West Seneca and Syracuse takes 3h 54m and the fastest bus takes 3h 27m. There is a bus service every few hours from West Seneca to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between West Seneca and Syracuse. The earliest departure is at 5:08 AM in the morning, and the last departure from West Seneca is at 11:35 PM which arrives into Syracuse at 3:05 AM. All services require a transfer at North Division Street & Oak Street and take an average of 3h 54m. The schedules shown below are for the next available departures.

3h 49m • 1 change

3h 34m • 1 change

4h 26m • 1 change

4h 26m • 1 change

4h 6m • 1 change

3h 27m • 1 change

3h 32m • 1 change

3h 49m • 1 change

4h 11m • 1 change

3h 27m • 1 change

3h 32m • 1 change

3h 49m • 1 change

4h 11m • 1 change

3h 27m • 1 change

3h 32m • 1 change

3h 49m • 1 change

4h 6m • 1 change

3h 27m • 1 change

3h 32m • 1 change

3h 49m • 1 change
Want to know about travelling from West Seneca to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from West Seneca to Syracuse. However, there are services departing from West Seneca station and arriving at Syracuse station via Syracuse Bus Station station. The journey, including transfers, takes approximately 3h 54m.
West Seneca to Syracuse bus services, operated by NFTA, depart from Buffalo station.
West Seneca to Syracuse bus services, operated by NFTA, arrive at Syracuse Bus Station.
The distance between West Seneca and Syracuse is 217 km. The road distance is 248 km.
Greyhound USA operates a bus from Buffalo to Syracuse Bus Station every 3 hours. Tickets cost $22–45 and the journey takes 2h 25m. Two other operators also service this route.