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Wheeling to Buffalo buses

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Trip Overview

The average bus between Wheeling and Buffalo takes 21h 29m and the fastest bus takes 20h 55m. The bus runs, on average, 6 times per week from Wheeling to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 29m
Duration
288 mi
Distance
$62
Average price
6 times a week
Frequency

Wheeling to Buffalo bus times

Buses run 6 times a week between Wheeling and Buffalo. The earliest departure is at 4:25 PM in the afternoon, and the last departure from Wheeling is at 7:50 PM which arrives into Buffalo at 4:45 PM. All services require a transfer at Pittsburgh Intermodal Station and take an average of 21h 29m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA20h 55m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA20h 55m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA20h 55m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA20h 55m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA20h 55m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA24h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Wheeling to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Wheeling to Buffalo.ExpandLaunch map view
  • Distance: 287.7 mi
  • Duration: 21h 29m

What companies run services between Wheeling, WV, USA and Buffalo, NY, USA?

You can take a bus from Wheeling Bus Stop to Buffalo via Pittsburgh Intermodal Station and Erie in around 8h 20m.

Operators