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Winston-Salem to Indianapolis buses

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Trip Overview

The bus between Winston-Salem and Indianapolis takes 21h 50m. The bus runs, on average, 5 times per week from Winston-Salem to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 50m
Duration
603 mi
Distance
$115
Average price
5 times a week
Frequency

Winston-Salem to Indianapolis bus times

Buses run 5 times a week between Winston-Salem and Indianapolis. The service departs Winston-Salem at 3:25 PM in the afternoon, which arrives into Indianapolis at 13:15:00. All services require a transfer at Winston Salem and take an average of 21h 50m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Sunway ChartersBarons BusCOTAFlixbus USA21h 50m • 3 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Sunway ChartersBarons BusCOTAFlixbus USA21h 50m • 3 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Sunway ChartersBarons BusCOTAFlixbus USA21h 50m • 3 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Sunway ChartersBarons BusCOTAFlixbus USA21h 50m • 3 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Sunway ChartersBarons BusCOTAFlixbus USA21h 50m • 3 changes

Frequently asked questions

Want to know about travelling from Winston-Salem to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Winston-Salem to Indianapolis.ExpandLaunch map view
  • Distance: 603.3 mi
  • Duration: 21h 50m

What companies run services between Winston-Salem, NC, USA and Indianapolis, IN, USA?

You can take a bus from Baptist Hospital to Indianapolis via Winston Salem, Columbus, S Grant Ave & E Mound St, S High St & E Rich St, and Columbus in around 15h 14m.

Operators