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Winston-Salem to Opelika buses

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Trip Overview

The average bus between Winston-Salem and Opelika takes 15h 32m and the fastest bus takes 15h 25m. The bus service runs several times per day from Winston-Salem to Opelika. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 32m
Duration
447 mi
Distance
$120
Average price
Twice daily
Frequency

Winston-Salem to Opelika bus times

Buses run twice daily between Winston-Salem and Opelika. The earliest departure is at 6:55 AM in the morning, and the last departure from Winston-Salem is at 6:20 PM which arrives into Opelika at 8:45 AM. All services require a transfer at Charlotte Bus Station and take an average of 15h 32m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

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    Greyhound USAGreyhound USA15h 40m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Departing Monday, November 9, 2026

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    Greyhound USAGreyhound USA15h 40m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Greyhound USAGreyhound USA15h 40m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Greyhound USAGreyhound USA15h 40m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAGreyhound USA15h 40m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USAGreyhound USA15h 40m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA15h 25m • 1 change

Frequently asked questions

Want to know about travelling from Winston-Salem to Opelika? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Winston-Salem to Opelika.ExpandLaunch map view
  • Distance: 447.5 mi
  • Duration: 15h 32m

What companies run services between Winston-Salem, NC, USA and Opelika, AL, USA?

You can take a bus from Winston Salem(Trans Center) to Opelika 4th Street Station via Charlotte Bus Station, Atlanta Downtown, Civic Center Station, Doraville Station, and Atlanta in around 9h 51m.

Operators