The average bus between Worcester and Des Moines takes 40h 14m and the fastest bus takes 34h 55m. The bus service runs several times per day from Worcester to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Worcester and Des Moines. The earliest departure is at 2:40 AM at night, and the last departure from Worcester is at 12:15 PM which arrives into Des Moines at 11:10 PM. All services require a transfer at Newark Penn Station and take an average of 40h 14m. The schedules shown below are for the next available departures.
Arrives next day


39h 30m • 2 changes
Arrives next day


38h 45m • 2 changes
Arrives next day


39h 30m • 2 changes
Arrives next day


38h 45m • 2 changes
Want to know about travelling from Worcester to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Worcester to Des Moines. However, there are services departing from Worcester station and arriving at Des Moines station via Newark Penn Station station. The journey, including transfers, takes approximately 40h 14m.
Worcester to Des Moines bus services, operated by Greyhound USA, depart from Worcester Union Station.
Worcester to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
Book your Worcester to Des Moines bus tickets online with Greyhound USA, Flixbus USA and Burlington Trailways.
The distance between Worcester and Des Moines is 1,800.5 km. The road distance is 2,248 km.
You can take a bus from Worcester Union Station to Des Moines via Newark Penn Station and Chicago in around 29h 10m.