Rome2Rio

Wytheville to Niagara Falls buses

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Trip Overview

The bus between Wytheville and Niagara Falls takes 45h 20m. The bus runs, on average, 4 times per week from Wytheville to Niagara Falls. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 20m
Duration
649 mi
Distance
$139
Average price
4 times a week
Frequency

Wytheville to Niagara Falls bus times

Buses run 4 times a week between Wytheville and Niagara Falls. The service departs Wytheville at 12:10 PM in the afternoon, which arrives into Niagara Falls at 09:30:00. All services require a transfer at Charleston and take an average of 45h 20m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Virginia BreezeFlixbus USAFlixbus USA45h 20m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Virginia BreezeFlixbus USAFlixbus USA45h 20m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Virginia BreezeFlixbus USAFlixbus USA45h 20m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Virginia BreezeFlixbus USAFlixbus USA45h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Wytheville to Niagara Falls? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Wytheville to Niagara Falls.ExpandLaunch map view
  • Distance: 648.9 mi
  • Duration: 45h 20m

What companies run services between Wytheville, VA, USA and Niagara Falls, NY, USA?

You can take a vehicle from Wytheville to Main Street & Pine Avenue via Wytheville, Charleston, Akron, and Ellicott Street & MTC Static in around 15h 18m.

Operators