The average train between Alessandria and Siena takes 6h 48m and the fastest train takes 4h 51m. The train service runs several times per day from Alessandria to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Alessandria and Siena. The earliest departure is at 6:49 AM in the morning, and the last departure from Alessandria is at 9:16 PM which arrives into Siena at 9:38 AM. All services require a transfer at Voghera and take an average of 6h 48m. The schedules shown below are for the next available departures.



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5h 51m • 3 changes


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4h 51m • 3 changes


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5h 51m • 3 changes


7h 24m • 3 changesWant to know about travelling from Alessandria to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Alessandria to Siena. However, there are services departing from Alessandria station and arriving at Siena station via Milano Rogoredo. The journey, including transfers, takes approximately 6h 48m.
Alessandria to Siena train services, operated by Trenord, depart from Voghera station.
Alessandria to Siena train services, operated by Trenord, arrive at Siena station.
Book your Alessandria to Siena train tickets online with Trenord, Trenitalia and 2 other operators.
The distance between Alessandria and Siena is 280.1 km. The road distance is 482 km.
You can take a train from Alessandria to Siena via Voghera, Milano Rogoredo, and Firenze S.M.N. in around 5h 29m.