Amsterdam to Mendrisio Trains

Amsterdam to Mendrisio trains

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Trip Overview

The average train between Amsterdam and Mendrisio takes 12h 50m and the fastest train takes 11h 38m. The train service runs several times per day from Amsterdam to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 50m
Duration: 1,021 km
Distance: CHF 191
Average price: 5 times a day
Frequency

Train

best

Take the train from Amsterdam Centraal to Frankfurt(M) Flughafen Fernbftrain Ice
Take the train from Frankfurt to Basel SBBtrain 43
Take the train from Basel SBB to Luganotrain Ec

11h 14m

CHF 93–324

Amsterdam to Mendrisio train times

Trains run 5 times a day between Amsterdam and Mendrisio. The earliest departure is at 6:10 AM in the morning, and the last departure from Amsterdam is at 9:01 PM which arrives into Mendrisio at 10:18 AM. All services require a transfer at Frankfurt and take an average of 12h 50m. The schedules shown below are for the next available departures.

Departing Thursday, October 15, 2026

12:38 PM → 12:27 AM
Arrives next day
11h 49m • 3 changes
9:01 PM → 10:18 AM
Arrives next day
13h 17m • 3 changes

Departing Friday, October 16, 2026

6:38 AM → 6:18 PM
11h 40m • 3 changes
8:31 AM → 8:18 PM
11h 47m • 3 changes
10:31 AM → 10:27 PM
11h 56m • 3 changes
12:33 PM → 12:27 AM
Arrives next day
11h 54m • 3 changes
Show more

Departing Saturday, October 17, 2026

6:38 AM → 6:18 PM
11h 40m • 3 changes
8:31 AM → 8:18 PM
11h 47m • 3 changes
10:31 AM → 10:27 PM
11h 56m • 3 changes
12:33 PM → 12:27 AM
Arrives next day
11h 54m • 3 changes
Show more

Departing Sunday, October 18, 2026

6:40 AM → 6:18 PM
11h 38m • 3 changes
8:31 AM → 8:18 PM
11h 47m • 3 changes
12:33 PM → 12:27 AM
Arrives next day
11h 54m • 3 changes
8:15 PM → 10:18 AM
Arrives next day
14h 3m • 3 changes

Departing Monday, October 19, 2026

6:38 AM → 6:18 PM
11h 40m • 3 changes
8:31 AM → 8:18 PM
11h 47m • 3 changes
10:31 AM → 10:27 PM
11h 56m • 3 changes
12:38 PM → 12:27 AM
Arrives next day
11h 49m • 3 changes
Show more

Departing Tuesday, October 20, 2026

6:10 AM → 6:18 PM
12h 8m • 3 changes
8:10 AM → 8:18 PM
12h 8m • 3 changes
10:10 AM → 10:27 PM
12h 17m • 3 changes
12:10 PM → 12:27 AM
Arrives next day
12h 17m • 3 changes
Show more

Departing Wednesday, October 21, 2026

6:10 AM → 6:18 PM
12h 8m • 3 changes
8:10 AM → 8:18 PM
12h 8m • 3 changes
10:10 AM → 10:27 PM
12h 17m • 3 changes

Frequently asked questions

Want to know about travelling from Amsterdam to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.