The average train between Avignon-Centre Station and Lyon takes 1h 38m and the fastest train takes 1h 15m. There is a train service every few hours from Avignon-Centre Station to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Avignon-Centre Station and Lyon. The earliest departure is at 6:13 AM in the morning, and the last departure from Avignon-Centre Station is at 8:13 PM which arrives into Lyon at 10:01 PM. All services require a transfer, and take on average 1h 38m. The schedules shown below are for the next available departures.

2h 7m • 1 change
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1h 41m • 1 change
1h 15m • 1 change
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1h 36m • 1 change
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1h 41m • 1 changeWant to know about travelling from Avignon-Centre Station to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Avignon-Centre Station to Lyon. However, there are services departing from Avignon Tgv station and arriving at Lyon Part Dieu station via Lyon Part Dieu station. The journey, including transfers, takes approximately 1h 38m.
Avignon-Centre Station to Lyon train services, operated by TGV inOui, depart from Avignon Tgv station.
Avignon-Centre Station to Lyon train services, operated by TGV inOui, arrive at Lyon Part Dieu station.
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The distance between Avignon-Centre Station and Lyon is 200.9 km. The road distance is 225 km.
TGV inOui operates a train from Avignon Tgv to Lyon Part Dieu hourly. Tickets cost €45–70 and the journey takes 1h 4m. Three other operators also service this route.