The average train between Avignon Centre and Lyon takes 1h 37m and the fastest train takes 1h 15m. There is a train service every few hours from Avignon Centre to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Avignon Centre and Lyon. The earliest departure is at 6:13 AM in the morning, and the last departure from Avignon Centre is at 8:13 PM which arrives into Lyon at 10:00 PM. All services require a transfer, and take on average 1h 37m. The schedules shown below are for the next available departures.

1h 36m • 1 change

1h 41m • 1 change

1h 38m • 1 change

1h 41m • 1 change

2h 7m • 1 change

1h 27m • 1 change

1h 36m • 1 change

1h 41m • 1 change

2h 7m • 1 change

1h 27m • 1 change

1h 36m • 1 change

1h 41m • 1 change

2h 7m • 1 change

1h 27m • 1 change

1h 36m • 1 change

1h 41m • 1 change

2h 7m • 1 change

1h 27m • 1 change

1h 36m • 1 change

1h 41m • 1 change
Want to know about travelling from Avignon Centre to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Avignon Centre to Lyon. However, there are services departing from Avignon Centre station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 1h 37m.
Avignon Centre to Lyon train services, operated by Zou! Lignes Express Régionales, depart from Avignon Tgv station.
Avignon Centre to Lyon train services, operated by Zou! Lignes Express Régionales, arrive at Lyon Part Dieu station.
Book your Avignon Centre to Lyon train tickets online with Zou! Lignes Express Régionales, TGV inOui and Trenitalia.
The distance between Avignon Centre and Lyon is 200.9 km. The road distance is 231 km.
TGV inOui operates a train from Avignon Tgv to Lyon Part Dieu hourly. Tickets cost €45–75 and the journey takes 1h 7m. Trenitalia also services this route twice daily.