The average train between Avignon and Karlsruhe takes 9h 47m and the fastest train takes 6h 1m. The train service runs several times per day from Avignon to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Avignon and Karlsruhe. The earliest departure is at 8:49 AM in the morning, and the last departure from Avignon is at 4:33 PM which arrives into Karlsruhe at 9:26 AM. All services require a transfer, and take on average 9h 47m. The schedules shown below are for the next available departures.

6h 1m • 1 change

7h 30m • 1 change
Arrives next day

16h 53m • 1 change

6h 1m • 1 change

7h 30m • 1 change
Arrives next day

16h 53m • 1 change

6h 1m • 1 change

7h 30m • 1 change
Arrives next day

16h 53m • 1 change

6h 1m • 1 change

7h 30m • 1 change
Arrives next day

16h 53m • 1 change
Want to know about travelling from Avignon to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Avignon to Karlsruhe. However, there are services departing from Avignon station and arriving at Karlsruhe station via Strasbourg. The journey, including transfers, takes approximately 9h 47m.
Avignon to Karlsruhe train services, operated by TGV inOui, depart from Avignon Tgv station.
Avignon to Karlsruhe train services, operated by TGV inOui, arrive at Karlsruhe Hbf station.
Book your Avignon to Karlsruhe train tickets online with TGV inOui, Deutsche Bahn Intercity (DB IC) and Société Nationale des Chemins de fer Français (SNCF).
The distance between Avignon and Karlsruhe is 626.3 km. The road distance is 804 km.
You can take a train from Avignon Tgv to Karlsruhe Hbf via Strasbourg in around 6h 7m.