The average train between Bologna and Isernia takes 6h 33m and the fastest train takes 4h 41m. The train service runs several times per day from Bologna to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Bologna and Isernia. The earliest departure is at 9:57 AM in the morning, and the last departure from Bologna is at 8:57 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 6h 33m. The schedules shown below are for the next available departures.

5h 26m • 1 change

4h 58m • 1 change

5h 9m • 1 change
Arrives next day

11h 30m • 1 change

5h 26m • 1 change

4h 58m • 1 change

5h 9m • 1 change
Arrives next day

11h 30m • 1 change

5h 26m • 1 change

4h 58m • 1 change

5h 9m • 1 change
Arrives next day

11h 30m • 1 change

5h 26m • 1 change

4h 58m • 1 change

5h 9m • 1 change
Arrives next day

11h 30m • 1 change
Want to know about travelling from Bologna to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Bologna to Isernia. However, there are services departing from Bologna station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 6h 33m.
Bologna to Isernia train services, operated by ItaloTreno, depart from Bologna centrale station.
Bologna to Isernia train services, operated by ItaloTreno, arrive at Isernia station.
Book your Bologna to Isernia train tickets online with ItaloTreno and Trenitalia.
The distance between Bologna and Isernia is 398.9 km. The road distance is 535 km.
You can take a train from Bologna centrale to Isernia via Roma Termini in around 5h 24m.