The average train between Brindisi and Domodossola takes 14h 4m and the fastest train takes 10h 26m. The train service runs several times per day from Brindisi to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Brindisi and Domodossola. The earliest departure is at 6:17 AM in the morning, and the last departure from Brindisi is at 9:17 PM which arrives into Domodossola at 9:43 AM. All services require a transfer, and take on average 14h 4m. The schedules shown below are for the next available departures.

12h 26m • 1 change

11h 16m • 1 change
Arrives next day

20h 29m • 1 change

12h 26m • 1 change

11h 16m • 1 change
Arrives next day

20h 29m • 1 change
Arrives next day

12h 26m • 1 change

12h 26m • 1 change

11h 16m • 1 change
Arrives next day

20h 29m • 1 change
Arrives next day

12h 26m • 1 change

12h 26m • 1 change

11h 16m • 1 change
Arrives next day

20h 29m • 1 change
Want to know about travelling from Brindisi to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brindisi to Domodossola. However, there are services departing from Brindisi station and arriving at Domodossola station via Milano Centrale. The journey, including transfers, takes approximately 14h 4m.
Brindisi to Domodossola train services, operated by Trenitalia Intercity, depart from Brindisi station.
Brindisi to Domodossola train services, operated by Trenitalia Intercity, arrive at Domodossola station.
Book your Brindisi to Domodossola train tickets online with Trenitalia Intercity, Trenitalia EuroCity and Trenitalia Frecce.
The distance between Brindisi and Domodossola is 988.4 km. The road distance is 1,090 km.
You can take a train from Brindisi to Domodossola via Milano Centrale in around 11h 9m.