The average train between Brindisi and Vatican Museums takes 6h 2m and the fastest train takes 5h 43m. The train service runs several times per day from Brindisi to Vatican Museums. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Brindisi and Vatican Museums. The earliest departure is at 6:29 AM in the morning, and the last departure from Brindisi is at 5:23 PM which arrives into Vatican Museums at 11:18 PM. All services require a transfer at Rome Termini and take an average of 6h 2m. The schedules shown below are for the next available departures.

5h 58m • 1 change

5h 50m • 1 change

6h 39m • 1 change

5h 55m • 1 change

5h 52m • 1 change

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6h 39m • 1 change

5h 52m • 1 change

5h 59m • 1 change

5h 43m • 1 change

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6h 38m • 1 change

5h 52m • 1 change

5h 58m • 1 change

5h 50m • 1 change

6h 39m • 1 change

5h 52m • 1 change

5h 58m • 1 change

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6h 39m • 1 change

5h 52m • 1 change

5h 58m • 1 change

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6h 39m • 1 change
Want to know about travelling from Brindisi to Vatican Museums? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brindisi to Vatican Museums. However, there are services departing from Brindisi station and arriving at Vatican Museums station via Roma Termini. The journey, including transfers, takes approximately 6h 2m.
Brindisi to Vatican Museums train services, operated by Trenitalia Frecce, depart from Brindisi station.
Brindisi to Vatican Museums train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
The distance between Brindisi and Vatican Museums is 479.4 km. The road distance is 593 km.
Trenitalia Frecce operates a train from Brindisi to Roma Termini every 2 hours. Tickets cost €85–170 and the journey takes 5h 41m.