The average train between Brno and Domažlice takes 5h 58m and the fastest train takes 5h 12m. The train service runs several times per day from Brno to Domažlice. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Brno and Domažlice. The earliest departure is at 3:10 AM at night, and the last departure from Brno is at 9:46 PM which arrives into Domažlice at 7:58 AM. All services require a transfer, and take on average 5h 58m. The schedules shown below are for the next available departures.

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6h 48m • 1 change

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Want to know about travelling from Brno to Domažlice? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Domažlice. However, there are services departing from Brno station and arriving at Domažlice station via Praha Hlavni Nadrazi. The journey, including transfers, takes approximately 5h 58m.
Brno to Domažlice train services, operated by RegioJet, depart from Brno Hlavni Nadrazi station.
Brno to Domažlice train services, operated by RegioJet, arrive at Domazlice station.
Book your Brno to Domažlice train tickets online with RegioJet, ÖBB EuroCity and 2 other operators.
The distance between Brno and Domažlice is 268 km. The road distance is 410 km.
You can take a train from Brno Hlavni Nadrazi to Domazlice via Praha Hlavni Nadrazi in around 5h 46m.