The average train between Brno and Mainz takes 10h 21m and the fastest train takes 9h. The train service runs several times per day from Brno to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Brno and Mainz. The earliest departure is at 7:18 AM in the morning, and the last departure from Brno is at 10:18 PM which arrives into Mainz at 12:18 PM. All services require a transfer, and take on average 10h 21m. The schedules shown below are for the next available departures.

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10h 26m • 1 change
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10h 48m • 1 changeWant to know about travelling from Brno to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Mainz. However, there are services departing from Brno Hlavni Nadrazi station and arriving at Mainz Hbf station via Wien Hbf station. The journey, including transfers, takes approximately 10h 21m.
Brno to Mainz train services, operated by České dráhy (ČD), depart from Brno Hlavni Nadrazi station.
Brno to Mainz train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Mainz Hbf station.
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The distance between Brno and Mainz is 606.4 km. The road distance is 743 km.
You can take a train from Brno Hlavni Nadrazi to Mainz Hbf via Wien Hbf in around 9h 36m.