The average train between Brno and Niš takes 25h 6m and the fastest train takes 23h 41m. The train service runs several times per day from Brno to Niš. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Brno and Niš. The earliest departure is at 10:18 AM in the morning, and the last departure from Brno is at 4:18 PM which arrives into Niš at 8:06 PM. All services require a transfer at Budapest-Nyugati and take an average of 25h 6m. The schedules shown below are for the next available departures.
Arrives next day




23h 41m • 4 changes
Arrives next day




23h 50m • 4 changes
Arrives next day




27h 48m • 4 changes
Arrives next day




23h 41m • 4 changes
Arrives next day




23h 50m • 4 changes
Arrives next day




27h 48m • 4 changes
Arrives next day




23h 41m • 4 changes
Arrives next day




23h 50m • 4 changes
Arrives next day




27h 48m • 4 changes
Want to know about travelling from Brno to Niš? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Niš. However, there are services departing from Brno station and arriving at Niš station via Budapest-Nyugati. The journey, including transfers, takes approximately 25h 6m.
Brno to Niš train services, operated by ÖBB EuroCity, depart from Brno Hlavni Nadrazi station.
Brno to Niš train services, operated by ÖBB EuroCity, arrive at Nis station.
The distance between Brno and Niš is 768.9 km. The road distance is 1,014 km.
You can take a train from Brno Hlavni Nadrazi to Nis via Budapest-Nyugati, Szeged, Subotica, and Beograd Centar in around 18h 2m.