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Buffalo to Florence trains

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Trip Overview

The average train between Buffalo and Florence takes 27h 7m and the fastest train takes 22h 42m. The train service runs several times per day from Buffalo to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

27h 7m
Duration
1,070 mi
Distance
$693
Average price
Twice daily
Frequency

Buffalo to Florence train times

Trains run twice daily between Buffalo and Florence. The earliest departure is at 4:28 AM at night, and the last departure from Buffalo is at 12:25 PM which arrives into Florence at 8:43 PM. All services require a transfer, and take on average 27h 7m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

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    Arrives next day

    AmtrakAmtrak22h 42m • 1 change
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    Arrives next day

    AmtrakAmtrak32h 18m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    AmtrakAmtrak22h 42m • 1 change
  •  → 

    Arrives next day

    AmtrakAmtrak32h 18m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    AmtrakAmtrak22h 42m • 1 change
  •  → 

    Arrives next day

    AmtrakAmtrak32h 18m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    AmtrakAmtrak22h 42m • 1 change
  •  → 

    Arrives next day

    AmtrakAmtrak32h 18m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    AmtrakAmtrak22h 42m • 1 change
  •  → 

    Arrives next day

    AmtrakAmtrak32h 18m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    AmtrakAmtrak22h 42m • 1 change

Frequently asked questions

Want to know about travelling from Buffalo to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Florence.ExpandLaunch map view
  • Distance: 1,069.9 mi
  • Duration: 27h 7m

What companies run services between Buffalo, NY, USA and Florence, SC, USA?

You can take a train from Buffalo to Florence Station via Ny Moynihan Train Hall At Penn Station in around 23h 58m.

Operators