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Buffalo to La Crosse trains

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Trip Overview

The train between Buffalo and La Crosse takes 28h 46m. The train runs, on average, 6 times per week from Buffalo to La Crosse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 46m
Duration
814 mi
Distance
$552
Average price
6 times a week
Frequency

Buffalo to La Crosse train times

Trains run 6 times a week between Buffalo and La Crosse. The service departs Buffalo at 12:25 PM in the afternoon, which arrives into La Crosse at 16:11:00. All services require a transfer at Buffalo Depew Station and take an average of 28h 46m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    VIA RailAmtrakAmtrak28h 46m • 2 changes

Frequently asked questions

Want to know about travelling from Buffalo to La Crosse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to La Crosse.ExpandLaunch map view
  • Distance: 813.8 mi
  • Duration: 28h 46m

What companies run services between Buffalo, NY, USA and La Crosse, WI, USA?

You can take a train from Buffalo to La Crosse Amtrak Station via Buffalo Depew Station and Chicago Union Station in around 17h 49m.

Operators