The average train between Canton of Lucerne and Domodossola takes 3h 53m and the fastest train takes 2h 53m. The train service runs several times per day from Canton of Lucerne to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Canton of Lucerne and Domodossola. The earliest departure is at 6:00 AM in the morning, and the last departure from Canton of Lucerne is at 11:00 PM which arrives into Domodossola at 8:10 AM. All services require a transfer at Bern and take an average of 3h 53m. The schedules shown below are for the next available departures.


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Want to know about travelling from Canton of Lucerne to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Canton of Lucerne to Domodossola. However, there are services departing from Canton of Lucerne station and arriving at Domodossola station via Bern. The journey, including transfers, takes approximately 3h 53m.
Canton of Lucerne to Domodossola train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Luzern station.
Canton of Lucerne to Domodossola train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Brig station.
Book your Canton of Lucerne to Domodossola train tickets online with Swiss Federal Railways (SBB CFF FFS) and BLS AG.
The distance between Canton of Lucerne and Domodossola is 108.7 km. The road distance is 250 km.
You can take a train from Luzern to Domodossola via Bern and Brig in around 4h 5m.