The average train between Cassino and Brindisi takes 6h 51m and the fastest train takes 6h 5m. The train service runs several times per day from Cassino to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Cassino and Brindisi. The earliest departure is at 6:39 AM in the morning, and the last departure from Cassino is at 7:46 PM which arrives into Brindisi at 1:54 PM. All services require a transfer, and take on average 6h 51m. The schedules shown below are for the next available departures.

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6h 5m • 1 changeWant to know about travelling from Cassino to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Cassino to Brindisi. However, there are services departing from Cassino station and arriving at Brindisi station via Caserta. The journey, including transfers, takes approximately 6h 51m.
Cassino to Brindisi train services, operated by Trenitalia, depart from Cassino station.
Cassino to Brindisi train services, operated by Trenitalia, arrive at Brindisi station.
Book your Cassino to Brindisi train tickets online with Trenitalia, Trenitalia Frecce and Trenitalia Intercity.
The distance between Cassino and Brindisi is 357.2 km. The road distance is 469 km.
You can take a train from Cassino to Brindisi via Caserta in around 6h 38m.