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Cassino to Siena trains

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Trip Overview

The average train between Cassino and Siena takes 4h 51m and the fastest train takes 4h 35m. There is at least one train per day from Cassino to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 51m
Duration
489 km
Distance
€77
Average price
Once daily
Frequency

Cassino to Siena train times

Trains run once daily between Cassino and Siena. The service departs Cassino at 6:05 AM in the morning, which arrives into Siena at 10:40:00. All services require a transfer, and take on average 4h 51m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Trenitalia FrecceTrenitalia4h 35m • 1 change

Departing Wednesday, November 4, 2026

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    Trenitalia FrecceTrenitalia4h 35m • 1 change

Departing Thursday, November 5, 2026

  •  → 

    Trenitalia FrecceTrenitalia4h 35m • 1 change

Departing Friday, November 6, 2026

  •  → 

    Trenitalia FrecceTrenitalia4h 35m • 1 change

Departing Saturday, November 7, 2026

  •  → 

    Trenitalia FrecceTrenitalia4h 35m • 1 change

Departing Sunday, November 8, 2026

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    Trenitalia FrecceTrenitalia6h 33m • 1 change

Departing Monday, November 9, 2026

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    Trenitalia FrecceTrenitalia4h 35m • 1 change

Frequently asked questions

Want to know about travelling from Cassino to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Cassino to Siena.ExpandLaunch map view
  • Distance: 489.1 km
  • Duration: 4h 51m

What companies run services between Cassino, Lazio, Italy and Siena, Italy?

You can take a train from Cassino to Siena via Firenze S.M.N. in around 5h 23m.

Operators