The average train between Düsseldorf and Prague takes 10h 37m and the fastest train takes 8h 26m. The train service runs several times per day from Düsseldorf to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Düsseldorf and Prague. The earliest departure is at 4:46 AM at night, and the last departure from Düsseldorf is at 11:51 PM which arrives into Prague at 10:57 AM. All services require a transfer at S Südkreuz Bhf and take an average of 10h 37m. The schedules shown below are for the next available departures.

8h 57m • 1 change

8h 27m • 1 change
Arrives next day

16h 6m • 1 change

8h 57m • 1 change

8h 27m • 1 change
Arrives next day

11h 26m • 1 change

8h 26m • 1 change

8h 27m • 1 change
Arrives next day

11h 23m • 1 change
Want to know about travelling from Düsseldorf to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Düsseldorf to Prague. However, there are services departing from Düsseldorf station and arriving at Prague station via S Südkreuz Bhf. The journey, including transfers, takes approximately 10h 37m.
Düsseldorf to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Düsseldorf Hbf station.
Düsseldorf to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha-Holesovice station.
Book your Düsseldorf to Prague train tickets online with Deutsche Bahn Intercity (DB IC) and Danish Railways (DSB).
The distance between Düsseldorf and Prague is 553.2 km. The road distance is 903 km.
You can take a train from Düsseldorf Hbf to Praha-Holesovice via S Südkreuz Bhf and Berlin Suedkreuz in around 9h 8m.