The average train between Domodossola and Alessandria takes 7h 29m and the fastest train takes 2h 56m. The train service runs several times per day from Domodossola to Alessandria. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Domodossola and Alessandria. The earliest departure is at 6:17 AM in the morning, and the last departure from Domodossola is at 6:48 PM which arrives into Alessandria at 7:13 AM. All services require a transfer, and take on average 7h 29m. The schedules shown below are for the next available departures.

2h 56m • 1 change

8h 44m • 1 change

3h 30m • 1 change
Arrives next day

12h 25m • 1 change

2h 56m • 1 change

8h 44m • 1 change

3h 30m • 1 change
Arrives next day

14h 25m • 1 change

8h 44m • 1 change

7h 40m • 1 change
Arrives next day

14h 25m • 1 change

8h 44m • 1 change

7h 40m • 1 change
Arrives next day

12h 25m • 1 change
Want to know about travelling from Domodossola to Alessandria? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Alessandria. However, there are services departing from Domodossola station and arriving at Alessandria station via Novara. The journey, including transfers, takes approximately 7h 29m.
Domodossola to Alessandria train services, operated by Trenitalia, depart from Domodossola station.
Domodossola to Alessandria train services, operated by Trenitalia, arrive at Alessandria station.
Book your Domodossola to Alessandria train tickets online with Trenitalia.
The distance between Domodossola and Alessandria is 136.5 km. The road distance is 155 km.
You can take a train from Domodossola to Alessandria via Novara in around 4h 3m.