The average train between Domodossola and Brussels takes 13h 3m and the fastest train takes 9h 50m. The train service runs several times per day from Domodossola to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Domodossola and Brussels. The earliest departure is at 4:35 AM at night, and the last departure from Domodossola is at 2:48 PM which arrives into Brussels at 8:45 AM. All services require a transfer at Brig and take an average of 13h 3m. The schedules shown below are for the next available departures.





9h 50m • 5 changes





10h 59m • 5 changes
Arrives next day





19h 29m • 5 changes





11h 23m • 5 changes





10h 59m • 5 changes
Arrives next day





19h 29m • 5 changes





11h 23m • 5 changes





10h 59m • 5 changes
Arrives next day





19h 29m • 5 changes





11h 3m • 5 changes





10h 59m • 5 changes
Arrives next day





19h 29m • 5 changes
Want to know about travelling from Domodossola to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Brussels. However, there are services departing from Domodossola station and arriving at Brussels station via Basel SBB. The journey, including transfers, takes approximately 13h 3m.
Domodossola to Brussels train services, operated by Trenitalia EuroCity, depart from Brig station.
Domodossola to Brussels train services, operated by Trenitalia EuroCity, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Domodossola to Brussels train tickets online with Trenitalia EuroCity, Swiss Federal Railways (SBB CFF FFS) and 5 other operators.
The distance between Domodossola and Brussels is 601.1 km. The road distance is 1,129 km.
You can take a train from Domodossola to Brussel-Zuid / Bruxelles-Midi via Brig, Basel SBB, Basel SBB, Saint-Louis, St Louis, Strasbourg, Paris Est, and Paris Nord in around 9h 45m.