The average train between Domodossola and Firenze Santa Maria Novella takes 6h 40m and the fastest train takes 4h 10m. The train service runs several times per day from Domodossola to Firenze Santa Maria Novella. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Domodossola and Firenze Santa Maria Novella. The earliest departure is at 6:06 AM in the morning, and the last departure from Domodossola is at 8:06 PM which arrives into Firenze Santa Maria Novella at 8:35 AM. All services require a transfer, and take on average 6h 40m. The schedules shown below are for the next available departures.

4h 29m • 1 change

4h 29m • 1 change

5h 29m • 1 change

4h 29m • 1 change

4h 29m • 1 change

4h 10m • 1 change
Arrives next day

12h 29m • 1 change
Want to know about travelling from Domodossola to Firenze Santa Maria Novella? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Firenze Santa Maria Novella. However, there are services departing from Domodossola station and arriving at Firenze Santa Maria Novella station via Rho-Fiera Milano. The journey, including transfers, takes approximately 6h 40m.
Domodossola to Firenze Santa Maria Novella train services, operated by Trenitalia, depart from Domodossola station.
Domodossola to Firenze Santa Maria Novella train services, operated by Trenitalia, arrive at Firenze Santa Maria Novella station.
The distance between Domodossola and Firenze Santa Maria Novella is 348 km. The road distance is 424 km.
You can take a train from Domodossola to Firenze Santa Maria Novella via Milano Rogoredo in around 4h 52m.