The average train between Domodossola and Lake Lucerne takes 5h 21m and the fastest train takes 4h 17m. The train service runs several times per day from Domodossola to Lake Lucerne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Domodossola and Lake Lucerne. The earliest departure is at 8:26 AM in the morning, and the last departure from Domodossola is at 8:26 PM which arrives into Lake Lucerne at 9:43 AM. All services require a transfer at Brig and take an average of 5h 21m. The schedules shown below are for the next available departures.

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Want to know about travelling from Domodossola to Lake Lucerne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Lake Lucerne. However, there are services departing from Domodossola station and arriving at Lake Lucerne station via Bern. The journey, including transfers, takes approximately 5h 21m.
Domodossola to Lake Lucerne train services, operated by FART, depart from Brig station.
Domodossola to Lake Lucerne train services, operated by FART, arrive at Luzern station.
Book your Domodossola to Lake Lucerne train tickets online with FART and Schweizerische Südostbahn AG.
The distance between Domodossola and Lake Lucerne is 100.4 km. The road distance is 251 km.
You can take a train from Domodossola to Luzern, Werkhofstrasse via Brig, Bern, Luzern, and Luzern, Bundesplatz in around 3h 45m.