The average train between Domodossola and Lyon takes 8h 23m and the fastest train takes 5h 17m. The train service runs several times per day from Domodossola to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Domodossola and Lyon. The earliest departure is at 9:48 AM in the morning, and the last departure from Domodossola is at 8:48 PM which arrives into Lyon at 10:24 AM. All services require a transfer at Genève and take an average of 8h 23m. The schedules shown below are for the next available departures.


7h 34m • 2 changes


6h 34m • 2 changes
Arrives next day


10h 34m • 2 changes


7h 34m • 2 changes


6h 34m • 2 changes
Arrives next day


10h 34m • 2 changes


7h 34m • 2 changes


6h 34m • 2 changes
Arrives next day


10h 34m • 2 changes
Want to know about travelling from Domodossola to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Lyon. However, there are services departing from Domodossola station and arriving at Lyon station via Genève. The journey, including transfers, takes approximately 8h 23m.
Domodossola to Lyon train services, operated by Trenitalia EuroCity, depart from Domodossola station.
Domodossola to Lyon train services, operated by Trenitalia EuroCity, arrive at Lyon Part Dieu station.
Book your Domodossola to Lyon train tickets online with Trenitalia EuroCity, Swiss Federal Railways (SBB CFF FFS) and 2 other operators.
The distance between Domodossola and Lyon is 269.6 km. The road distance is 404 km.
You can take a train from Domodossola to Lyon Part Dieu via Genève and Bellegarde in around 5h 54m.