The average train between Domodossola and Mendrisio takes 3h 22m and the fastest train takes 3h 15m. The train service runs several times per day from Domodossola to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Domodossola and Mendrisio. The earliest departure is at 8:26 AM in the morning, and the last departure from Domodossola is at 8:26 PM which arrives into Mendrisio at 7:18 AM. All services require a transfer, and take on average 3h 22m. The schedules shown below are for the next available departures.

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3h 15m • 1 changeWant to know about travelling from Domodossola to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Mendrisio. However, there are services departing from Domodossola station and arriving at Mendrisio station via Locarno FART. The journey, including transfers, takes approximately 3h 22m.
Domodossola to Mendrisio train services, operated by FART, depart from Domodossola station.
Domodossola to Mendrisio train services, operated by FART, arrive at Mendrisio station.
Book your Domodossola to Mendrisio train tickets online with FART and Swiss Federal Railways (SBB CFF FFS).
The distance between Domodossola and Mendrisio is 60.2 km. The road distance is 99 km.
You can take a train from Domodossola to Mendrisio via Locarno in around 3h 4m.