The average train between Domodossola and Piacenza takes 3h 41m and the fastest train takes 2h 29m. The train service runs several times per day from Domodossola to Piacenza. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Domodossola and Piacenza. The earliest departure is at 9:17 AM in the morning, and the last departure from Domodossola is at 9:17 PM which arrives into Piacenza at 5:44 AM. All services require a transfer, and take on average 3h 41m. The schedules shown below are for the next available departures.

2h 36m • 1 change

3h 25m • 1 change

2h 49m • 1 change

2h 40m • 1 change
Want to know about travelling from Domodossola to Piacenza? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Piacenza. However, there are services departing from Domodossola station and arriving at Piacenza station via Milano Centrale. The journey, including transfers, takes approximately 3h 41m.
Domodossola to Piacenza train services, operated by Trenitalia EuroCity, depart from Domodossola station.
Domodossola to Piacenza train services, operated by Trenitalia EuroCity, arrive at Piacenza station.
Book your Domodossola to Piacenza train tickets online with Trenitalia EuroCity, Trenitalia Frecce and Trenitalia Intercity.
The distance between Domodossola and Piacenza is 160.9 km. The road distance is 191 km.
You can take a train from Domodossola to Piacenza via Milano Centrale in around 2h 50m.