The average train between Domodossola and Prague takes 19h 45m and the fastest train takes 15h 46m. The train service runs several times per day from Domodossola to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Domodossola and Prague. The earliest departure is at 4:35 AM at night, and the last departure from Domodossola is at 6:48 PM which arrives into Prague at 12:21 PM. All services require a transfer at Brig and take an average of 19h 45m. The schedules shown below are for the next available departures.





15h 46m • 5 changes





16h 24m • 5 changes
Arrives next day





24h 33m • 5 changes
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17h 33m • 5 changes





15h 46m • 5 changes





16h 24m • 5 changes
Arrives next day





24h 33m • 5 changes
Arrives next day





17h 33m • 5 changes





15h 46m • 5 changes





16h 24m • 5 changes
Arrives next day





24h 33m • 5 changes
Arrives next day





17h 33m • 5 changes
Want to know about travelling from Domodossola to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Prague. However, there are services departing from Domodossola station and arriving at Prague station via Basel SBB. The journey, including transfers, takes approximately 19h 45m.
Domodossola to Prague train services, operated by Trenitalia EuroCity, depart from Brig station.
Domodossola to Prague train services, operated by Trenitalia EuroCity, arrive at Praha Hlavni Nadrazi station.
Book your Domodossola to Prague train tickets online with Trenitalia EuroCity, Deutsche Bahn Intercity (DB IC) and 6 other operators.
The distance between Domodossola and Prague is 633.7 km. The road distance is 1,137 km.
You can take a train from Domodossola to Praha Hlavni Nadrazi via Brig, Basel SBB, Frankfurt, Nürnberg Hbf, and Schwandorf in around 15h 43m.