The average train between Domodossola and Rome takes 6h 54m and the fastest train takes 5h 19m. The train service runs several times per day from Domodossola to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Domodossola and Rome. The earliest departure is at 6:06 AM in the morning, and the last departure from Domodossola is at 8:06 PM which arrives into Rome at 9:19 AM. All services require a transfer, and take on average 6h 54m. The schedules shown below are for the next available departures.

5h 19m • 1 change
5h 59m • 1 change
5h 19m • 1 change
5h 24m • 1 change
5h 19m • 1 change
6h 24m • 1 change
5h 19m • 1 change
5h 24m • 1 changeWant to know about travelling from Domodossola to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Domodossola to Rome. However, there are services departing from Domodossola station and arriving at Roma Termini station via Rho-Fiera Milano station. The journey, including transfers, takes approximately 6h 54m.
Domodossola to Rome train services, operated by Trenitalia, depart from Domodossola station.
Domodossola to Rome train services, operated by ItaloTreno, arrive at Roma Termini station.
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The distance between Domodossola and Rome is 576.8 km. The road distance is 698 km.
You can take a train from Domodossola to Roma Termini via Milano Rogoredo in around 5h 55m.