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Domodossola to Sicily trains

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Trip Overview

The average train between Domodossola and Sicily takes 29h 39m and the fastest train takes 27h 19m. The train service runs several times per day from Domodossola to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

29h 39m
Duration
1,553 km
Distance
€222
Average price
Twice daily
Frequency

Domodossola to Sicily train times

Trains run twice daily between Domodossola and Sicily. The earliest departure is at 4:06 PM in the afternoon, and the last departure from Domodossola is at 8:06 PM which arrives into Sicily at 4:16 AM. All services require a transfer at Milano Rogoredo and take an average of 29h 39m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 23m • 3 changes
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    Arrives +2 days

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia32h 10m • 3 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 23m • 3 changes
  •  → 

    Arrives +2 days

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia32h 10m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 23m • 3 changes
  •  → 

    Arrives +2 days

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia32h 10m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 23m • 3 changes
  •  → 

    Arrives +2 days

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia32h 53m • 3 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 19m • 3 changes
  •  → 

    Arrives +2 days

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia32h 10m • 3 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    TrenitaliaItaloTrenoTrenitalia IntercityTrenitalia27h 53m • 3 changes

Frequently asked questions

Want to know about travelling from Domodossola to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Domodossola to Sicily.ExpandLaunch map view
  • Distance: 1,553.2 km
  • Duration: 29h 39m

What companies run services between Domodossola, Italy and Sicily, Italy?

You can take a train from Domodossola to Palermo Notarbartolo via Milano Rogoredo, Roma Termini, and Palermo Centrale in around 19h 3m.

Operators