The average train between Dos Hermanas and Madrid takes 3h 51m and the fastest train takes 3h 2m. There is a train service every few hours from Dos Hermanas to Madrid. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Dos Hermanas and Madrid. The earliest departure is at 7:12 AM in the morning, and the last departure from Dos Hermanas is at 11:12 PM which arrives into Madrid at 8:53 AM. All services require a transfer, and take on average 3h 51m. The schedules shown below are for the next available departures.

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3h 5m • 1 changeWant to know about travelling from Dos Hermanas to Madrid? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Dos Hermanas to Madrid. However, there are services departing from Sevilla-Santa Justa station and arriving at Madrid-Puerta de Atocha-Almudena Grandes station via Madrid-Puerta de Atocha-Almudena Grandes station. The journey, including transfers, takes approximately 3h 51m.
Dos Hermanas to Madrid train services, operated by Renfe AVE, depart from Sevilla-Santa Justa station.
Dos Hermanas to Madrid train services, operated by Renfe AVE, arrive at Madrid-Puerta de Atocha-Almudena Grandes station.
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The distance between Dos Hermanas and Madrid is 397.9 km. The road distance is 534 km.
Renfe AVE operates a train from Sevilla-Santa Justa to Madrid-Puerta de Atocha-Almudena Grandes hourly. Tickets cost €60–110 and the journey takes 2h 39m. Three other operators also service this route.