The train between Duisburg and Enschede takes 2h 32m. There is a train service every few hours from Duisburg to Enschede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Duisburg and Enschede. The earliest departure is at 5:25 AM in the morning, and the last departure from Duisburg is at 8:25 PM which arrives into Enschede at 10:57 PM. All services require a transfer, and take on average 2h 32m. The schedules shown below are for the next available departures.

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Want to know about travelling from Duisburg to Enschede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Duisburg to Enschede. However, there are services departing from Duisburg station and arriving at Enschede station via Dülmen, Bahnhof. The journey, including transfers, takes approximately 2h 32m.
Duisburg to Enschede train services, operated by Deutsche Bahn Regio (DB Regional), depart from Duisburg Hbf station.
Duisburg to Enschede train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Enschede station.
Book your Duisburg to Enschede train tickets online with Deutsche Bahn Regio (DB Regional).
The distance between Duisburg and Enschede is 87.8 km. The road distance is 133 km.
You can take a train from Duisburg Hbf to Enschede via Dülmen, Bahnhof in around 3h.