The average train between Eisenach and Karlsruhe takes 3h 23m and the fastest train takes 3h 10m. There is a train service every few hours from Eisenach to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Eisenach and Karlsruhe. The earliest departure is at 6:48 AM in the morning, and the last departure from Eisenach is at 8:48 PM which arrives into Karlsruhe at 11:59 PM. All services require a transfer, and take on average 3h 23m. The schedules shown below are for the next available departures.

3h 11m • 1 change

3h 11m • 1 change

3h 27m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 27m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 27m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 11m • 1 change

3h 27m • 1 change

3h 11m • 1 change
Want to know about travelling from Eisenach to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Eisenach to Karlsruhe. However, there are services departing from Eisenach station and arriving at Karlsruhe station via Frankfurt. The journey, including transfers, takes approximately 3h 23m.
Eisenach to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), depart from Eisenach Hbf station.
Eisenach to Karlsruhe train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Karlsruhe Hauptbahnhof station.
Book your Eisenach to Karlsruhe train tickets online with Deutsche Bahn Intercity (DB IC).
The distance between Eisenach and Karlsruhe is 258.3 km. The road distance is 336 km.
You can take a train from Eisenach Hbf to Karlsruhe Hauptbahnhof via Frankfurt in around 3h 36m.