The average train between Eisenach and Prague takes 6h 49m and the fastest train takes 5h 48m. The train service runs several times per day from Eisenach to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Eisenach and Prague. The earliest departure is at 11:10 AM in the morning, and the last departure from Eisenach is at 9:10 PM which arrives into Prague at 10:57 AM. All services require a transfer, and take on average 6h 49m. The schedules shown below are for the next available departures.

6h 5m • 1 change

6h 5m • 1 change
Arrives next day

5h 48m • 1 change

6h 5m • 1 change

6h 5m • 1 change
Arrives next day

5h 48m • 1 change

6h 5m • 1 change
Arrives next day

5h 48m • 1 change
Arrives next day

13h 47m • 1 change
Want to know about travelling from Eisenach to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Eisenach to Prague. However, there are services departing from Eisenach station and arriving at Prague station via Dresden Hauptbahnhof. The journey, including transfers, takes approximately 6h 49m.
Eisenach to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Eisenach Hbf station.
Eisenach to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha-Holesovice station.
Book your Eisenach to Prague train tickets online with Deutsche Bahn Intercity (DB IC), LE and Danish Railways (DSB).
The distance between Eisenach and Prague is 306.6 km. The road distance is 476 km.
You can take a train from Eisenach Hbf to Praha-Holesovice via Dresden Hbf in around 5h 38m.