The average train between Enschede and Mannheim takes 5h 15m and the fastest train takes 4h 52m. There is a train service every few hours from Enschede to Mannheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Enschede and Mannheim. The earliest departure is at 6:26 AM in the morning, and the last departure from Enschede is at 11:33 PM which arrives into Mannheim at 9:25 AM. All services require a transfer, and take on average 5h 15m. The schedules shown below are for the next available departures.

4h 52m • 1 change
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4h 52m • 1 changeArrives next day

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4h 53m • 1 changeWant to know about travelling from Enschede to Mannheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Enschede to Mannheim. However, there are services departing from Enschede station and arriving at Mannheim station via Münster Hauptbahnhof. The journey, including transfers, takes approximately 5h 15m.
Enschede to Mannheim train services, operated by Nederlandse Spoorwegen (NS), depart from Enschede station.
Enschede to Mannheim train services, operated by Nederlandse Spoorwegen (NS), arrive at Mannheim, Hauptbahnhof station.
Book your Enschede to Mannheim train tickets online with Nederlandse Spoorwegen (NS) and Deutsche Bahn Intercity (DB IC).
The distance between Enschede and Mannheim is 322.9 km. The road distance is 455 km.
You can take a train from Enschede to Mannheim, Hauptbahnhof via Münster Hauptbahnhof in around 5h 14m.