The average train between Essen and Heilbronn takes 4h 19m and the fastest train takes 3h 49m. There is a train service every few hours from Essen to Heilbronn. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Essen and Heilbronn. The earliest departure is at 6:00 AM in the morning, and the last departure from Essen is at 11:03 PM which arrives into Heilbronn at 7:53 AM. All services require a transfer, and take on average 4h 19m. The schedules shown below are for the next available departures.

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3h 49m • 1 changeWant to know about travelling from Essen to Heilbronn? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Essen to Heilbronn. However, there are services departing from Essen Hbf station and arriving at Heilbronn Hauptbahnhof station via Mannheim, Hauptbahnhof station. The journey, including transfers, takes approximately 4h 19m.
Essen to Heilbronn train services, operated by Deutsche Bahn Intercity (DB IC), depart from Essen Hbf station.
Essen to Heilbronn train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Heilbronn Hauptbahnhof station.
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The distance between Essen and Heilbronn is 301.6 km. The road distance is 374 km.
You can take a train from Essen Hbf to Heilbronn Hauptbahnhof via Mannheim, Hauptbahnhof in around 4h 20m.