The average train between Florence and Domodossola takes 5h 25m and the fastest train takes 3h 48m. The train service runs several times per day from Florence to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Florence and Domodossola. The earliest departure is at 7:55 AM in the morning, and the last departure from Florence is at 9:55 PM which arrives into Domodossola at 8:43 AM. All services require a transfer, and take on average 5h 25m. The schedules shown below are for the next available departures.

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Want to know about travelling from Florence to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Domodossola. However, there are services departing from Florence station and arriving at Domodossola station via Milano Centrale. The journey, including transfers, takes approximately 5h 25m.
Florence to Domodossola train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
Florence to Domodossola train services, operated by Trenitalia Frecce, arrive at Domodossola station.
Book your Florence to Domodossola train tickets online with Trenitalia Frecce and Trenitalia EuroCity.
The distance between Florence and Domodossola is 348.6 km. The road distance is 425 km.
You can take a train from Firenze S.M.N. to Domodossola via Milano Centrale in around 4h 24m.