Florence to Isernia Trains

Florence to Isernia trains

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Trip Overview

The average train between Florence and Isernia takes 5h 20m and the fastest train takes 3h 52m. The train service runs several times per day from Florence to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 20m
Duration: 447 km
Distance: €65
Average price: 5 times a day
Frequency

Train (Trenitalia)

best

Take the train from Firenze S.M.N. to Roma Terminitrain Fr
Take the train from Roma Termini to Iserniatrain Re

4h 44m

€52–115

Florence to Isernia train times

Trains run 5 times a day between Florence and Isernia. The earliest departure is at 7:05 AM in the morning, and the last departure from Florence is at 10:14 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 5h 20m. The schedules shown below are for the next available departures.

Departing Tuesday, September 8, 2026

6:14 PM → 10:26 PM
4h 12m • 1 change
10:14 PM → 8:27 AM
Arrives next day
10h 13m • 1 change

Departing Wednesday, September 9, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
11:14 AM → 3:23 PM
4h 9m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
6:14 PM → 10:26 PM
4h 12m • 1 change
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Departing Thursday, September 10, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
11:14 AM → 3:23 PM
4h 9m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
6:14 PM → 10:26 PM
4h 12m • 1 change
Show more

Departing Friday, September 11, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
11:14 AM → 3:23 PM
4h 9m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
6:14 PM → 10:26 PM
4h 12m • 1 change
Show more

Departing Saturday, September 12, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
11:14 AM → 3:23 PM
4h 9m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
6:14 PM → 10:26 PM
4h 12m • 1 change
Show more

Departing Sunday, September 13, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
3:48 PM → 7:55 PM
4h 7m • 1 change
6:14 PM → 10:23 PM
4h 9m • 1 change
Show more

Departing Monday, September 14, 2026

7:05 AM → 11:15 AM
4h 10m • 1 change
11:14 AM → 3:23 PM
4h 9m • 1 change
12:48 PM → 4:40 PM
3h 52m • 1 change
6:14 PM → 10:26 PM
4h 12m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.