The average train between Florence and Lissone takes 3h 3m and the fastest train takes 2h 36m. There is a train service every few hours from Florence to Lissone. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Florence and Lissone. The earliest departure is at 7:25 AM in the morning, and the last departure from Florence is at 9:25 PM which arrives into Lissone at 6:17 AM. All services require a transfer at Milano Centrale and take an average of 3h 3m. The schedules shown below are for the next available departures.


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes


2h 36m • 2 changes
Want to know about travelling from Florence to Lissone? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Lissone. However, there are services departing from Florence station and arriving at Lissone station via Milano Centrale. The journey, including transfers, takes approximately 3h 3m.
Florence to Lissone train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Florence to Lissone train services, operated by ItaloTreno, arrive at Milano Centrale station.
Book your Florence to Lissone train tickets online with ItaloTreno and Trenord.
The distance between Florence and Lissone is 258.2 km. The road distance is 320 km.
ItaloTreno operates a train from Firenze Santa Maria Novella to Milano Centrale hourly. Tickets cost €35–75 and the journey takes 1h 55m.