The average train between Florence and Mainz takes 13h 16m and the fastest train takes 10h 53m. The train service runs several times per day from Florence to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Florence and Mainz. The earliest departure is at 7:25 AM in the morning, and the last departure from Florence is at 9:25 PM which arrives into Mainz at 3:18 PM. All services require a transfer at Milano Centrale and take an average of 13h 16m. The schedules shown below are for the next available departures.



11h 18m • 3 changes



10h 53m • 3 changes



11h 28m • 3 changes
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14h 13m • 3 changes



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10h 53m • 3 changes



11h 28m • 3 changes
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11h 18m • 3 changes



10h 53m • 3 changes



11h 28m • 3 changes
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14h 13m • 3 changes



11h 18m • 3 changes



10h 53m • 3 changes



11h 28m • 3 changes
Arrives next day



14h 13m • 3 changes



11h 18m • 3 changes



10h 53m • 3 changes
Arrives next day



17h 18m • 3 changes
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17h 53m • 3 changes



11h 18m • 3 changes



10h 53m • 3 changes



11h 28m • 3 changes
Arrives next day



17h 18m • 3 changes
Want to know about travelling from Florence to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Mainz. However, there are services departing from Florence station and arriving at Mainz station via Milano Centrale. The journey, including transfers, takes approximately 13h 16m.
Florence to Mainz train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Florence to Mainz train services, operated by ItaloTreno, arrive at Mainz, Hauptbahnhof station.
Book your Florence to Mainz train tickets online with ItaloTreno, Trenitalia EuroCity and 3 other operators.
The distance between Florence and Mainz is 725.7 km. The road distance is 989 km.
You can take a train from Firenze Santa Maria Novella to Mainz, Hauptbahnhof via Milano Centrale, Basel SBB, and Mannheim, Hauptbahnhof in around 10h 40m.